Can any body tell me what is base calling and calling SNPs?
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I think it depends on the context...
But I'd say that "base calling" is the method by which some software looks at the raw data from your instrument, probably some kind of fluorescence, and decides whether there is an A,C,G or T there.
SNP calling involves comparing this info to a reference sequence, and if there is a discrepancy, deciding if the quality is good enough to justify saying "your sample has a variation"
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by seqadmin
The sequencing world is rapidly changing due to declining costs, enhanced accuracies, and the advent of newer, cutting-edge instruments. Equally important to these developments are improvements in sequencing analysis, a process that converts vast amounts of raw data into a comprehensible and meaningful form. This complex task requires expertise and the right analysis tools. In this article, we highlight the progress and innovation in sequencing analysis by reviewing several of the...-
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by seqadmin
The field of epigenetics has traditionally concentrated more on DNA and how changes like methylation and phosphorylation of histones impact gene expression and regulation. However, our increased understanding of RNA modifications and their importance in cellular processes has led to a rise in epitranscriptomics research. “Epitranscriptomics brings together the concepts of epigenetics and gene expression,” explained Adrien Leger, PhD, Principal Research Scientist...-
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04-22-2024, 07:01 AM -
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