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If you do happen to perform such a comparison, please do post a link to it here and/or on biostars, since I expect many people would find it interesting.
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Why not download a real data set from NCBI and then randomly sample from that to derive pseudo-data sets of varying read depths? That way you would have an realistic baseline to compare to.Originally posted by Zimbobo View PostMichael Black, Ph.D.
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Note that the person you're replying to posted that ~4 years ago...Originally posted by mbblack View PostComment
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The field of epigenetics has traditionally concentrated more on DNA and how changes like methylation and phosphorylation of histones impact gene expression and regulation. However, our increased understanding of RNA modifications and their importance in cellular processes has led to a rise in epitranscriptomics research. “Epitranscriptomics brings together the concepts of epigenetics and gene expression,” explained Adrien Leger, PhD, Principal Research Scientist...04-22-2024, 07:01 AM -
Proteins are often described as the workhorses of the cell, and identifying their sequences is key to understanding their role in biological processes and disease. Currently, the most common technique used to determine protein sequences is mass spectrometry. While still a valuable tool, mass spectrometry faces several limitations and requires a highly experienced scientist familiar with the equipment to operate it. Additionally, other proteomic methods, like affinity assays, are constrained...04-04-2024, 04:25 PM
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