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  • Overlapping motif occurrences

    Hi I am using FIMO to find all the significant+non-significant occurrences of a motif in a set of input sequences.
    Sometimes I am getting an isolated motif occurrence and other times I am getting overlapping motif occurrences. Meaning motif #1 and motif #3 occur at the same position in the sequence and with same exact start and end. I am resolving this using the most significant occurrence. Another scenario is motif #1 and motif #3 occurrences overlap with each other but not entirely, sometimes the overlap can be 1 base pair or 3 base pair or 4 base pair. It varies. My question is if this is a problem when I consider there are 2 motifs at this location with overlapping occurrences or is this wrong to say that. Please comment.
    Thanks in advance.
    Last edited by mparida; 12-20-2016, 09:20 AM.

  • #2
    FIMO motif co-occurrences

    For anyone who is interested I found a valid answer from Charles E Grant.
    Biologically, a single site may bind to multiple transcription factors. In fact, the competition between TF for attachment to the binding site may be a key element of the regulatory system.

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