Hi,
I have NGS results (whole exomes, VCF files) for several family members with the same disease, and also the parents that are healthy.
Is there an available algorithm to calcultae LOD scores for linkage of variants to the disease? I.e. I would like to have the LOD score for each variant.
Or any other way to find the locus/loci associated with the disease.
Because I'm not sure the responsible mutation is realy in the exome (maybe it is intronic, or a long indel, or in an uncovered exon, etc).
Thanks!
I have NGS results (whole exomes, VCF files) for several family members with the same disease, and also the parents that are healthy.
Is there an available algorithm to calcultae LOD scores for linkage of variants to the disease? I.e. I would like to have the LOD score for each variant.
Or any other way to find the locus/loci associated with the disease.
Because I'm not sure the responsible mutation is realy in the exome (maybe it is intronic, or a long indel, or in an uncovered exon, etc).
Thanks!
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