PubMed: Correlation of global and gene-specific DNA methylation in maternal-infant pa

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Correlation of global and gene-specific DNA methylation in maternal-infant pairs.

PLoS One. 2010;5(10):e13730

Authors: Kile ML, Baccarelli A, Tarantini L, Hoffman E, Wright RO, Christiani DC

The inheritance of DNA methylation patterns is a popular theory to explain the influence of parental genetic and environmental factors on the phenotype of their offspring but few studies have examined this relationship in humans. Using 120 paired maternal-umbilical cord blood samples randomly selected from a prospective birth cohort in Bangladesh, we quantified DNA methylation by pyrosequencing seven CpG positions in the promoter region of p16, four CpG positions in the promoter region of p53, LINE-1 and Alu. Positive correlations were observed between maternal and umbilical cord blood at p16, LINE-1, and Alu but not p53. Multiple linear regression models observed a significant association between maternal and umbilical cord blood at LINE-1 and Alu (LINE-1: ? = 0.63, p

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11-10-2010, 07:20 AM	#1
Newsbot! RSS Posting Maniac Join Date: Feb 2008 Posts: 1,443	PubMed: Correlation of global and gene-specific DNA methylation in maternal-infant pa Syndicated from PubMed RSS Feeds Correlation of global and gene-specific DNA methylation in maternal-infant pairs. PLoS One. 2010;5(10):e13730 Authors: Kile ML, Baccarelli A, Tarantini L, Hoffman E, Wright RO, Christiani DC The inheritance of DNA methylation patterns is a popular theory to explain the influence of parental genetic and environmental factors on the phenotype of their offspring but few studies have examined this relationship in humans. Using 120 paired maternal-umbilical cord blood samples randomly selected from a prospective birth cohort in Bangladesh, we quantified DNA methylation by pyrosequencing seven CpG positions in the promoter region of p16, four CpG positions in the promoter region of p53, LINE-1 and Alu. Positive correlations were observed between maternal and umbilical cord blood at p16, LINE-1, and Alu but not p53. Multiple linear regression models observed a significant association between maternal and umbilical cord blood at LINE-1 and Alu (LINE-1: ? = 0.63, p