I am looking for ideas for sub-genomic sequencing experiments and I realy can use some help:
I would like to use at least 50 normal/tumor samples and will extract genomic DNA or RNA from it.
I am looking for a way to sequence my regions of interest (four genes that are 50-500kb in length) in all these samples and look at the genetic variations.
I read about some capture arrays? Will this be the best option? Hope you guys can help me decicde which method suits best for this and referring to literature will be extremly helpfull.
Much obliged!
I would like to use at least 50 normal/tumor samples and will extract genomic DNA or RNA from it.
I am looking for a way to sequence my regions of interest (four genes that are 50-500kb in length) in all these samples and look at the genetic variations.
I read about some capture arrays? Will this be the best option? Hope you guys can help me decicde which method suits best for this and referring to literature will be extremly helpfull.
Much obliged!
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