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Old 07-22-2015, 08:44 PM   #1
Location: Singapore

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Default Quantifying gene expression at the level of translation: Ribo-seq in tissue

We performed ribosome profiling of the heart and liver of two inbred rat strains. Our results suggest that:

- Ribo-seq is a better proxy for protein levels than RNA-seq
- There is widespread regulation of gene expression AFTER transcription
- Integration of RNA-seq and Ribo-seq reveals translational control and opens up a new level of gene regulation for further studies

Read the full manuscript here:

Translational regulation shapes the molecular landscape of complex disease phenotypes - Nature Communications

The Ribo-seq data used in this study is of course publicly available and we believe we have generated some of the deepest datasets to date with 5 biological replicates for each condition.
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Old 09-25-2015, 11:30 PM   #2
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thanks DerSeb

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Last edited by jack1090; 02-26-2016 at 03:36 AM.
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