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Old 07-02-2014, 02:45 AM   #1
IsBeth
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Default Mathematical fool

Hello!

Well my problem is that I'm a Biologist and so I've got no much statistical or mathematical background to understand some procedures in R. (I'm working in differential expression of RNA-seq data nowadays). What should I read or do to help me through? Are there some specific books or lessons that could be useful for people like me?

Thank you in advance!
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Old 07-02-2014, 09:26 AM   #2
dpryan
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Read through the DESeq2 vignette (or that from edgeR or limma). In particular, they generally have test datasets so you can follow along with how an analysis works. Other than that, you might try taking a short course on RNAseq from one of the many companies that seem to be popping up to offer that.
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Old 07-07-2014, 04:36 AM   #3
TiborNagy
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I am learn a lot from Coursera.
There is an article to help improving your skills:
http://www.ploscompbiol.org/article/...l.pcbi.1002632
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Old 07-08-2014, 05:27 AM   #4
Michael Love
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Rafael Irizarry and I put together the Data Analysis for Genomics class on edx.

Rafa's lectures (as well as all course content) are free to watch.

You could jump to the differential expression content in week 3, which covers statistical inference and linear models.

https://www.edx.org/course/harvardx/...-genomics-1401

The lecture notes are here (still be polished up):

http://genomicsclass.github.io/book/
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Old 07-18-2014, 06:15 AM   #5
IsBeth
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Thank you very much, all of you!

I think your advices and links will help me a lot
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