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  • Map genetic variants to protein domain/structure

    I got some genetic mutations or variants from exome sequencing data analysis. I am trying to map genetic mutations/variants to protein domain/structure. Ideally, I want to visualize the variants in linear protein domain diagram and 3D protein structure like this figure. I did research, but I can’t find good tools/databases for such work.

    I know similar questions have been asked here like https://www.biostars.org/p/61049/. But it is only the protein domain diagram (with no 3D structure), plus the protein domain annotation there seems to be limited.
    This question was asked at biostar: https://www.biostars.org/p/125929/. But I want to check if anybody here may have a answer/hint. Thanks!

  • #2
    PyMOL should be able to show these changes for 3D structures (provided a structure is available in PDB): http://pymol.org/ If your institution does not have a license then you may be able to use "education" version (if you qualify): http://pymol.org/educational/

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    • #3
      Thank you, Pymol looks like a good tool. Will try it out for the 3d structure.
      Anyone knows database and visualization tools for mapping genetic variants to protein domains?

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