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Old 01-08-2016, 09:56 AM   #1
vasvale
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Default How many missense/nonsense per coding Mb?

what is average number of missense/nonsense per Mb of coding DNA? I found 500 variants/Mb but that includes also synonimous.
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Old 01-08-2016, 10:22 AM   #2
GenoMax
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Please don't post the same question in multiple forums. That may not necessarily increase your chances of getting an answer.

As for your question: That is going to be dependent on the genome etc. I don't think there can be a single answer.

Last edited by GenoMax; 01-08-2016 at 10:24 AM.
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Old 01-08-2016, 01:38 PM   #3
westerman
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Quote:
Originally Posted by vasvale View Post
what is average number of missense/nonsense per Mb of coding DNA? I found 500 variants/Mb but that includes also synonimous.
Yes, that sounds about right from the known human SNPs. That said, GenoMax is correct in that it will depend on the genome.
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Old 01-08-2016, 04:17 PM   #4
vasvale
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I am looking for average in human genomes, could not find info on exomes papers
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Old 04-18-2016, 01:30 AM   #5
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For the human genome I use 1/100 in the non-coding regions and 1/1000 in the coding regions. Per individual of course. This tends to be roughly true. But it will differ between non coding regions and between genes.
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