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A recent study published in Veterinary Clinical Pathology by Chu, C. P., & Nabity, M. B., provided a comprehensive assessment of the optimal miRNA isolation and library preparation methods for small RNA‐seq research using canine biofluids. For library prep analysis, they compared the NEXTFLEX® Small RNA-seq kit v3 and the Illumina® TruSeq® Small RNA-seq kit. The authors concluded that the NEXTFLEX® Small RNA-seq kit v3 is the optimal library preparation method for detection of potential biomarkers in canine serum and urine.
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The field of epigenetics has traditionally concentrated more on DNA and how changes like methylation and phosphorylation of histones impact gene expression and regulation. However, our increased understanding of RNA modifications and their importance in cellular processes has led to a rise in epitranscriptomics research. “Epitranscriptomics brings together the concepts of epigenetics and gene expression,” explained Adrien Leger, PhD, Principal Research Scientist on Modified Bases...Today, 07:01 AM -
Proteins are often described as the workhorses of the cell, and identifying their sequences is key to understanding their role in biological processes and disease. Currently, the most common technique used to determine protein sequences is mass spectrometry. While still a valuable tool, mass spectrometry faces several limitations and requires a highly experienced scientist familiar with the equipment to operate it. Additionally, other proteomic methods, like affinity assays, are constrained...04-04-2024, 04:25 PM