New sequencing technologies? Want to start another sequencing company?

bios90 · 10-12-2014, 09:47 AM

Anyone on top of new sequencing companies that are coming up? Off the top of my head I can list
- Base4
- 10X Technologies
- Eve Biomedical
- Quantapore
- Genapsys
- Anything else?

Does anyone know what these different companies are up to and when they will release products?

Also, will be nice to hear from anyone is brave enough to explore starting a new sequencing company. I have some ideas.

ECO · 10-12-2014, 12:36 PM

10x != sequencing AFAIK.

bios90 · 10-12-2014, 03:11 PM

10X Technologies website says they are a sequencing company, but not clear what approach the are using.

kmcarr · 10-13-2014, 06:30 AM

There appears to be two very similarly named companies which may be the source of the confusion.

10x Technology LLC of Libertyville, IL (http://www.10xtechnology.com) -- Micro-structure design & manufacturing (not sequencing).

10x Technologies in Pleasanton, CA (http://www.10xtechnologies.com) -- A single page web site saying they are developing new sequencing technologies; no other information provided there. Here is what they say on a job posting that went up just last week (http://www.biospace.com/jobs/job-lis...ngineer-338072):

Quote:

10X Technologies is a Silicon Valley start-up developing new technologies for breakthrough next generation sequencing applications. The core technology combines advances in chemistry, biochemistry, microfluidics and bioinformatics.

Still not a lot of information.

luc · 10-13-2014, 08:38 PM

Anybody taking bets that Steve Quake is involved in 10x?

austinso · 10-14-2014, 08:30 AM

Quote:

Originally Posted by luc

Anybody taking bets that Steve Quake is involved in 10x?

I will...but against

.

It seems that Quake's group is focused on Big Data these days rather than tech dev.

FWIW.

Austin

austinso · 01-12-2015, 02:58 PM

10X Genomics is out of the bag now:

http://www.forbes.com/sites/luketimm...na-sequencing/

ymc · 01-31-2015, 05:13 AM

Is X10 better than Moleculo?

NextGenSeq · 02-02-2015, 10:51 AM

AllSeq has a good summary of emerging sequencing technologies.

http://allseq.com/knowledgebank/emer...nologies/genia

lac302 · 02-02-2015, 01:27 PM

BioNano
http://www.bionanogenomics.com/products/

niroshan · 02-09-2015, 01:42 PM

Q-SEQ from QuantumDX

Alongside QuantuMDx's novel sequencing by synthesis (SBS) DNA sequencing chemistry deployed on its nanowire FET biosensors, QMDx is also developing a novel DNA sequencing technology named Q-SEQ™. This device will perform single molecule, direct read (i.e. no need for reagents or expensive fluorescent detectors), long DNA sequencing reads and is presently at the prototyping stage.

http://www.quantumdx.com/

Nabsys positional sequencing

Nabsys has designed semiconductor-based nanodetectors to enable direct electrical detection of tagged DNA.

http://nabsys.com/

larissa · 02-25-2015, 10:43 AM

I was not sure if to post this here or in the Solid forum, but I figured this would work too, so anyone knows what is going on (if anything) with the Solid platform? How commonly is it (still) used?

AllSeq · 02-26-2015, 10:02 AM

Quote:

Originally Posted by larissa

I was not sure if to post this here or in the Solid forum, but I figured this would work too, so anyone knows what is going on (if anything) with the Solid platform? How commonly is it (still) used?

This is probably best in the SOLiD platform. But to answer your question, "Not much". On our Sequencing Marketplace, we haven't had a single request for the SOLiD platform. The unsurprising #1 request was Illumina at ~83%. #2 was a tie between PacBio and Ion Torrent (~7% each).

larissa · 03-02-2015, 06:47 AM

Thanks AllSeq for the info! Btw, your knowledge base is quite helpful.

Jessica_L · 07-02-2015, 08:49 AM

Looks like GenapSys is trying to get some press via the Sigma Aldrich website, but none of the links go anywhere.

GenoMax · 07-02-2015, 08:56 AM

GenomeWeb reported yesterday that Sigma-Aldrich was going to co-market the Genius sequencer. There was no launch date mentioned.

niroshan · 01-14-2016, 12:49 PM

At the JP Morgan Healthcare Conference, NanoString Technologies CEO Brad Gray said that the firm has been developing a novel single-molecule hybridization-based sequencing chemistry that leverages the company's optical barcoding technology.

Gray declined to provide details on the chemistry, which he dubbed Hyb&Seq, but said that it would be single-molecule, based on hybridization, and would not require amplification, the use of enzymes, or even library prep.
[Link to Genomeweb article]
[Link to NanoString Presentation]

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02-09-2015, 01:42 PM	#11
niroshan Member Location: Germany Join Date: Jun 2011 Posts: 10	Q-SEQ from QuantumDX Alongside QuantuMDx's novel sequencing by synthesis (SBS) DNA sequencing chemistry deployed on its nanowire FET biosensors, QMDx is also developing a novel DNA sequencing technology named Q-SEQ™. This device will perform single molecule, direct read (i.e. no need for reagents or expensive fluorescent detectors), long DNA sequencing reads and is presently at the prototyping stage. http://www.quantumdx.com/ Nabsys positional sequencing Nabsys has designed semiconductor-based nanodetectors to enable direct electrical detection of tagged DNA. http://nabsys.com/ Last edited by niroshan; 02-09-2015 at 01:50 PM.

01-14-2016, 12:49 PM	#17
niroshan Member Location: Germany Join Date: Jun 2011 Posts: 10	NanoString Developing Novel Sequencing Chemistry Based on Optical Barcoding At the JP Morgan Healthcare Conference, NanoString Technologies CEO Brad Gray said that the firm has been developing a novel single-molecule hybridization-based sequencing chemistry that leverages the company's optical barcoding technology. Gray declined to provide details on the chemistry, which he dubbed Hyb&Seq, but said that it would be single-molecule, based on hybridization, and would not require amplification, the use of enzymes, or even library prep. [Link to Genomeweb article] [Link to NanoString Presentation]

10-12-2014, 09:47 AM	#1
bios90 Junior Member Location: MA Join Date: Aug 2013 Posts: 8	New sequencing technologies? Want to start another sequencing company? Anyone on top of new sequencing companies that are coming up? Off the top of my head I can list - Base4 - 10X Technologies - Eve Biomedical - Quantapore - Genapsys - Anything else? Does anyone know what these different companies are up to and when they will release products? Also, will be nice to hear from anyone is brave enough to explore starting a new sequencing company. I have some ideas.

10-12-2014, 12:36 PM	#2
ECO --Site Admin-- Location: SF Bay Area, CA, USA Join Date: Oct 2007 Posts: 1,358	10x != sequencing AFAIK.

10-12-2014, 03:11 PM	#3
bios90 Junior Member Location: MA Join Date: Aug 2013 Posts: 8	10X Technologies website says they are a sequencing company, but not clear what approach the are using.

10-13-2014, 08:38 PM	#5
luc Senior Member Location: US Join Date: Dec 2010 Posts: 453	Anybody taking bets that Steve Quake is involved in 10x?

01-12-2015, 02:58 PM	#7
austinso Member Location: Bay area Join Date: Jun 2012 Posts: 77	10X Genomics is out of the bag now: http://www.forbes.com/sites/luketimm...na-sequencing/

01-31-2015, 05:13 AM	#8
ymc Senior Member Location: Hong Kong Join Date: Mar 2010 Posts: 498	Is X10 better than Moleculo?

02-02-2015, 10:51 AM	#9
NextGenSeq Senior Member Location: USA Join Date: Apr 2009 Posts: 482	AllSeq has a good summary of emerging sequencing technologies. http://allseq.com/knowledgebank/emer...nologies/genia

02-02-2015, 01:27 PM	#10
lac302 Member Location: DE Join Date: Dec 2012 Posts: 65	BioNano http://www.bionanogenomics.com/products/

02-25-2015, 10:43 AM	#12
larissa Member Location: NC Join Date: Mar 2010 Posts: 15	I was not sure if to post this here or in the Solid forum, but I figured this would work too, so anyone knows what is going on (if anything) with the Solid platform? How commonly is it (still) used?

03-02-2015, 06:47 AM	#14
larissa Member Location: NC Join Date: Mar 2010 Posts: 15	Thanks AllSeq for the info! Btw, your knowledge base is quite helpful.

07-02-2015, 08:49 AM	#15
Jessica_L Senior Member Location: Washington, D.C. metro area Join Date: Feb 2010 Posts: 118	Looks like GenapSys is trying to get some press via the Sigma Aldrich website, but none of the links go anywhere.

07-02-2015, 08:56 AM	#16
GenoMax Senior Member Location: East Coast USA Join Date: Feb 2008 Posts: 7,087	GenomeWeb reported yesterday that Sigma-Aldrich was going to co-market the Genius sequencer. There was no launch date mentioned.