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  • Manage bioinformatics infrastructure

    I am an infrequent visitor to seqanswers. So please send me direct email ([email protected]) to inquire about this position.

    NorthShore University HealthSystem is a pre-eminent hospital system just north of Chicago and was ranked among the top 10 health systems of 2011 by Thomson-Reuters (http://www.reuters.com/article/2011/...11+HUG20110531). Our Center for Molecular Medicine aims to translate NGS genomics into discoveries that will improve the clinical care for our patients. NGS analysis is in a great flux with constant emergence of new analysis software and new standards of data representation. We are looking for a dynamic bioinformatics scientist who is passionate about bringing the promise of NGS technologies to fruition in a real clinical setting. If you are familiar with the various bioinformatics technologies and view them not as dry science but rather as tools to be deployed in an attempt to revolutionize clinical practice, this is the position for you.

    To be successful, you will have:
    1) An advanced degree in biology or computational biology. People with other degrees who have “on the job” experience in bioinformatics will also be considered.

    2) Two years experience dealing with HPC environments, preferably in a bioinformatics core facility.

    3) Knowledge of various public domain databases and tools like those at NCBI, EMBL, UCSC, Sanger Center etc.

    4) Experience with programming bioinformatics applications is a plus.

    Your duties will be to:
    1) Maintain the software infrastructure of the bioinformatics cluster.
    1a) Keep abreast of our analysis needs and ensure that the requisite software (open source or commercial) is up and running on our machine; update the versions as needed.
    1b) Keep abreast of the advancements in analysis software and propose new analysis paradigms in our projects.

    2) Maintain reference datasets.
    2a) Based on project needs, download and make available the requisite reference databases like the human genome, dbSNP, dbGaP, CGP etc.
    2b) Build automated download schedules to ensure the availability of best versions of reference data.

    3) Maintain user accounts. NGS projects are typically done by investigators whose expertise is not in bioinformatics.
    3a) Create and maintain user accounts on the bioinformatics server and applications.
    3b) Define and maintain access restrictions and security.
    3c) Organize training on bioinformatics software and analysis for users as needed.

    4) Liaise with Health IT to maintain the hardware. General hardware maintenance responsibilities will be with NorthShore’s Health IT department. You will be responsible for liaising with them to ensure upkeep of our cluster.
    4a) Monitor back up schedules and ensure we have sufficient redundancy.
    4b) Monitor upcoming needs for analysis and work with Health IT to upgrade processor capacity and storage as needed.
    Kamalakar Gulukota,
    Director,
    Center for Bioinformatics and Computational Biology
    NorthShore University Health System, [email protected]

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