Go Back   SEQanswers > Literature Watch

Similar Threads
Thread Thread Starter Forum Replies Last Post
NHGRI funds development of revolutionary DNA sequencing technologies strob The Pipeline 0 08-23-2011 11:07 PM
PubMed: Development and implementation of a highly-multiplexed SNP array for genetic Newsbot! Literature Watch 0 07-20-2011 10:30 AM
a brilliant idea on dna sequencing technology development Introductions 0 05-28-2011 09:27 PM
PubMed: Development and quantitative analyses of a universal rRNA-subtraction protoco Newsbot! Literature Watch 1 03-12-2010 05:41 PM
PubMed: Characterization of transcriptional complexity during berry development in Vi Newsbot! Literature Watch 0 02-02-2010 02:10 AM

Thread Tools
Old 10-11-2008, 05:09 AM   #1
RSS Posting Maniac

Join Date: Feb 2008
Posts: 1,443
Default PubMed: The development and impact of 454 sequencing.

Syndicated from PubMed RSS Feeds

The development and impact of 454 sequencing.

Nat Biotechnol. 2008 Oct;26(10):1117-24

Authors: Rothberg JM, Leamon JH

The 454 Sequencer has dramatically increased the volume of sequencing conducted by the scientific community and expanded the range of problems that can be addressed by the direct readouts of DNA sequence. Key breakthroughs in the development of the 454 sequencing platform included higher throughput, simplified all in vitro sample preparation and the miniaturization of sequencing chemistries, enabling massively parallel sequencing reactions to be carried out at a scale and cost not previously possible. Together with other recently released next-generation technologies, the 454 platform has started to democratize sequencing, providing individual laboratories with access to capacities that rival those previously found only at a handful of large sequencing centers. Over the past 18 months, 454 sequencing has led to a better understanding of the structure of the human genome, allowed the first non-Sanger sequence of an individual human and opened up new approaches to identify small RNAs. To make next-generation technologies more widely accessible, they must become easier to use and less costly. In the longer term, the principles established by 454 sequencing might reduce cost further, potentially enabling personalized genomics.

PMID: 18846085 [PubMed - in process]

Newsbot! is offline   Reply With Quote

Thread Tools

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off

All times are GMT -8. The time now is 08:13 PM.

Powered by vBulletin® Version 3.8.9
Copyright ©2000 - 2020, vBulletin Solutions, Inc.
Single Sign On provided by vBSSO