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Comparing mutations in 2 different tissue samples of the same patient
Hi all,
I recently got a pair of tissue samples from a patient who developed right-sided colorectal cancer and recovered from it 4 years ago. Now the same patient develops left-sided colorectal cancer. Thus, the surgeon would like us to help discover whether both cases of colorectal cancer are of the same cellular origin.
Thus, we sequenced the cancer tissues (right and left-sided cancers) and compared the genetic mutations in these 2 cases. If there are common mutations happen in both cancer tissues, we hypothesise that the right-sided colorectal cancer and left-sided colorectal cancer which happened in this patient share the same origin and vice versa.
And indeed we noticed there are a number of common mutations shared by both cancer tissues.
However, we would like to make sure these mutations have not arisen by chance.
Does anyone have an idea on how to do that? Your help is much appreciated!
I recently got a pair of tissue samples from a patient who developed right-sided colorectal cancer and recovered from it 4 years ago. Now the same patient develops left-sided colorectal cancer. Thus, the surgeon would like us to help discover whether both cases of colorectal cancer are of the same cellular origin.
Thus, we sequenced the cancer tissues (right and left-sided cancers) and compared the genetic mutations in these 2 cases. If there are common mutations happen in both cancer tissues, we hypothesise that the right-sided colorectal cancer and left-sided colorectal cancer which happened in this patient share the same origin and vice versa.
And indeed we noticed there are a number of common mutations shared by both cancer tissues.
However, we would like to make sure these mutations have not arisen by chance.
Does anyone have an idea on how to do that? Your help is much appreciated!