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  • ThermoRecruiter
    Junior Member
    • Dec 2014
    • 1

    Scientist III, BioInformatics - Thermo Fisher Scientific

    Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, with revenues of $17 billion and 50,000 employees in 50 countries. Our mission is to enable our customers to make the world healthier, cleaner and safer. We help our customers accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics and increase laboratory productivity. Our four premier brands - Life Technologies, Thermo Scientific, Fisher Scientific and Unity Lab Services - offer an unmatched combination of innovative technologies, purchasing convenience and comprehensive support. For more information, please visit www.thermofisher.com.

    THE POSITION:

    We are seeking an experienced and motivated bioinformatics scientist for developing cutting-edge applications based on Ion Torrent high-throughput sequencing technologies. The position offers an exciting opportunity to join a dedicated team at Carlsbad, CA, translating state-of-the-art sequencing data to research and clinical applications. Under supervision of a senior manager, the candidate is expected to focus on specific goals of real world impact. Strong communication skills, especially for presenting scientific results, keeping records and working collaboratively in a team are necessary.

    The candidate will divide efforts between improving the core technology of AmpliSeqTM and providing customized data analysis to support bench scientists. Key AmpliSeqTM responsibilities are supporting new product development and monitoring performance of existing panels. The bioinformatics scientist will apply sequence and structural methods to mitigate potential mechanisms for systematic sequencing bias. He/she will translate new product requirements into software prototypes and test in a fast-paced environment. Other data analysis tasks include tracking of sequencing quality metrics, variant calling diagnostics and genome annotations.


    REQUIREMENTS / EDUCATION:
    • Solid knowledge of next-generation sequencing analysis under the Linux environment, with good understanding of software engineering and data analysis principles.
    • Proficiencies in a scripting language (PERL or Python) and a statistical package (R or Matlab) are required, and C/C++/Java skills are big pluses.
    • Experience with PCR primer design, sequence and motif analysis is particularly welcome.
    • PhD graduates in relevant fields or industry veterans with equivalent experience are encouraged to apply.

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  • SEQadmin2
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    I’m not a sequencing expert. I’m a purification scientist who uses NGS to evaluate workflows my group develops. With this perspective, we think about the sample first and the NGS workflow second. The sequencer is an exceptionally honest reporter, but it can only report on what you give it, so whether you get clean, interpretable data from an NGS workflow is largely determined before you begin.

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  • SEQadmin2
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    Data variability is still an issue in sequencing technologies despite the advances in reproducibility and accuracy of these platforms. But the problem does not originate in the sequencing itself, but in the previous steps, before the sample reaches the sequencer.


    The first step is collection, followed by preservation and sample preparation for analysis. Most scientists overlook those steps, but not being careful might just be skewing the experiment’s results.
    ...
    06-02-2026, 10:05 AM

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