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The folks at RIKEN just published an important study in Nature Methods (pubmed, journal) which will likely have a big impact on the study of promoter structure and activity.
They outline two methods based on their original CAGE paper and the template-switching method of Cloonan, which enable specific enrichment of 5' capped RNAs.
They outline two methods based on their original CAGE paper and the template-switching method of Cloonan, which enable specific enrichment of 5' capped RNAs.