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I am involved in the microfluidic implementation of ChIP-seq. Of course, I have general understanding of the basic questions that chip-seq can answer, i.e. genome-wide occupancy of a given protein. However, given the long trial-error loops and long time spent on methodological details, little time remains for me to address the question in the title thoroughly.
Therefore I would like to ask you if you might be aware of notable examples in which ChIP-seq has actually been used not only to pinpoint protein occupancy genome-wide but also if this kind of information has been actually used to understand how genes are regulated by these proteins or, even better, if this information has been already translated to application like for example synthetic biology, genome engineering or even medicine.
Thank you in advance for your time.
What are the most notable examples of biological and maybe translational knowledge that has been built using ChIP-seq?
Therefore I would like to ask you if you might be aware of notable examples in which ChIP-seq has actually been used not only to pinpoint protein occupancy genome-wide but also if this kind of information has been actually used to understand how genes are regulated by these proteins or, even better, if this information has been already translated to application like for example synthetic biology, genome engineering or even medicine.
Thank you in advance for your time.
What are the most notable examples of biological and maybe translational knowledge that has been built using ChIP-seq?