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  • Scotty
    Junior Member
    • Sep 2010
    • 2
    #1

    Question: Is there another new methylated DNA base out there?

    Hi everyone,

    I am new in the field and have been reading some papers on DNA methylation. I realized that the focus in the past 20 years has really been on the methylated cytosine. I have several questions and would appreciate your insights:

    1. Has anyone in the past ruled out the possibility of other methylated bases e.g. methylated guanine, adenine or thymine as possible epigenetic markers?
    2. When was methylated cytosine first found? How was it discovered?
    3. Do you all think that there might be more DNA methylations that are yet to be discovered?

    Sorry if these questions sound ignorant to you, I am trying to learn a new field. Thank you!

    Scotty
    Tags: None
  • simonandrews
    Simon Andrews
    • May 2009
    • 870
    #2
    Well hydroxy-methyl cytosine certainly exists. Does that count?

    Comment

    • Scotty
      Junior Member
      • Sep 2010
      • 2
      #3
      Sure, Simon. Missed that one.

      What I was thinking is - what about methylated adenine, guanine and thymine? Is there any reason why people haven't looked into those for methylation? Or have people looked and found nothing?

      Comment

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