FastQC output: Do I trim these?

[wilson90]

I am looking at the per base quality score of my RNA-Seq data, and found that the quality looks great. (as attached)

But when I look at the per base sequence, the first 10 bases seems to be varying as if certain bases is preferred at certain positions. (as attached)

Do I trim these off?

[dpryan]

That's likely caused by the "random" priming, in which case there's no need to trim it off (and doing so wouldn't improve anything anyway).