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  • getting gene coordinates

    Hi Members,
    I have bunch of 350+ gene names. These are cancer causing gene to which drugs are approved.
    I want there chromosome name, start, end information.
    How do I get that?

    Kindly advise.
    Last edited by bio_informatics; 09-20-2014, 07:38 AM.
    Bioinformaticscally calm

  • #2
    Biomart is a good place to do this sort of thing.

    From the drop-downs, select "Ensembl Genes <X>", "Homo Sapiens <Y>".

    Filters > Gene > ID list, copy/paste you're 350+ genes into the box.

    Attributes > Gene, select your attributes of interest.

    Good luck!

    Comment


    • #3
      Thank you for prompt reply.

      I followed this, but getting a blank file [ only headers ].
      Also, the HTML preview/output consists of headers.




      Originally posted by bruce01 View Post
      Biomart is a good place to do this sort of thing.

      From the drop-downs, select "Ensembl Genes <X>", "Homo Sapiens <Y>".

      Filters > Gene > ID list, copy/paste you're 350+ genes into the box.

      Attributes > Gene, select your attributes of interest.

      Good luck!
      Bioinformaticscally calm

      Comment


      • #4
        Your gene ID's have to match the filter selection (kind of Gene ID's) you are making in BioMart. What kind of ID's do you have?

        Comment


        • #5
          You can probably find the information at pharmGKB (https://www.pharmgkb.org/downloads/) as well.

          Comment


          • #6
            I have gene name(s)- CARD11, ABL2, DICER1
            I was using these in GENE ID list.

            Originally posted by GenoMax View Post
            Your gene ID's have to match the filter selection (kind of Gene ID's) you are making in BioMart. What kind of ID's do you have?
            Bioinformaticscally calm

            Comment


            • #7
              This helps a lot.

              This is as per version GrCh 37.

              However, if I want as per 38. Are below filters(steps) correct (?) :-
              UCSC table:
              clade-->mammal, genome-->Human; Assembly--> Dec 2013 GrCh38; Group gene and gene predictions; track --> Refseq Genes; Table --> ref genes

              This has column --> name2


              Originally posted by GenoMax View Post
              You can probably find the information at pharmGKB (https://www.pharmgkb.org/downloads/) as well.
              Last edited by bio_informatics; 09-20-2014, 06:37 PM.
              Bioinformaticscally calm

              Comment


              • #8
                That looks right.

                For BioMart search: You should select "Filters" --> "ID_Limit_list" --> "HGNC symbol" in the drop-down.

                Comment


                • #9
                  Thank you for confirming.
                  HGNC Symbol path also worked.
                  Bioinformaticscally calm

                  Comment

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