A large, multi-laboratory collaboration is just underway at Yale University School of Medicine, with the goal of using next-generation deep sequencing to create a comprehensive Transcriptional Atlas of Human Brain Development. We are looking for two highly motivated and qualified postdocs to start immediately:
Our laboratory investigates how neuronal identities and synaptic circuits form during development, and how these mechanisms changed during evolution of the mammalian brain. We seek to identify species-specific evolutionary changes in gene expression, neuronal identity, and connectivity that may be important for the development and evolution of the human frontal cortex, and thus for this brain region’s higher cognitive functions such as speech and language. For further information please see the lab’s website, www.sestanlab.org, or email us at sestanlab_at_yale_dot_edu.
• Bioinformatics: at least one postdoctoral position is available immediately for an individual with experience handling high-volume, complex data sets, especially next-generation sequencing data. Familiarity specifically with Illumina (Solexa) Genome Analyzer sequencing methods, data, and analysis pipeline is desirable. Would prefer someone with experience with high-performance compute cluster practices and the unix environment, as well as programming languages such as perl, python, R, etc... PhD in Biostatistics or related field is required. In addition to collaborating with multiple labs and institutions on the generation of a public Human Brain Transcriptome Atlas database, there will be ample opportunity for independent projects and collaborations.
• ChIP-seq: One postdoctoral position is available for a candidate familiar with ChIP-seq, ChIP-chip, and related techniques. Background in neurobiology and/or developmental biology will be beneficial, but is not required. Project details are flexible, but responsibilities will include collaborating closely with the sequencing center and informatics specialists to analyze and interpret ChIP-seq data in the context of brain development. Potential independent projects include: mapping a given transcription factor's activity across human brain regions and developmental stages; discovery of novel enhancers and validation in animal models; evolutionary comparative analysis of enhancers...
Our laboratory investigates how neuronal identities and synaptic circuits form during development, and how these mechanisms changed during evolution of the mammalian brain. We seek to identify species-specific evolutionary changes in gene expression, neuronal identity, and connectivity that may be important for the development and evolution of the human frontal cortex, and thus for this brain region’s higher cognitive functions such as speech and language. For further information please see the lab’s website, www.sestanlab.org, or email us at sestanlab_at_yale_dot_edu.