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  • seqadmin
    Senior Member
    • Oct 2022
    • 729

    #1

    Scientific Collaboration Aims to Aid Northern White Rhino's Survival

    The fate of the northern white rhino (Ceratotherium simum cottoni) remains hanging by a thread with just two living females in existence. To combat this crisis, Colossal Biosciences, known for its focus on species preservation using advanced genetic technology, has partnered with BioRescue, a consortium dedicated to the conservation of the northern white rhino. Their joint efforts aim to restore the rhino's dwindling genetic diversity and counteract its slide toward extinction.

    This collaborative initiative seeks to harness both organizations' expertise in the advancement of wildlife conservation research and veterinary medicine. Their overarching goal is to devise strategies that can mitigate the ongoing sixth mass extinction event.

    Historically, the northern white rhino thrived in various regions spanning Uganda, Chad, Sudan, the Central African Republic, and the Democratic Republic of Congo. However, due to rampant poaching, these areas saw a stark depletion of this remarkable species over a decade ago. Currently, the only remaining individuals reside at the Ol Pejeta Conservancy in Kenya, having been born in the Czech ZOO Dvůr Králové.

    Prof. Dr. Thomas Hildebrandt, who has dedicated over two decades to conserving the northern white rhino, emphasized the gravity of the situation, noting that the survival of this species impacts thousands of other interconnected species. By leveraging Colossal's expertise in genetic technology, they hope to restore lost genetic links of the rhino's evolutionary history, complementing the innovative reproductive and stem cell methods already in place.

    Central to this endeavor will be assessing the genetic diversity of historic northern white rhino samples. This will provide an ethical foundation for enhancing the genetic variability of any potential future populations. Colossal's role will encompass genome sequencing and gene editing to augment genetic diversity, ensuring the species can better resist diseases and adapt to climate shifts.

    The collaboration plans to catalog museum samples of past northern white rhino specimens, encompassing everything from bones and dried skin to preserved organs. By sequencing these samples, researchers can explore the species' past genetic diversity. Identifying gaps in genetic pools from these specimens, the teams plan to use gene editing to rejuvenate this lost diversity. Furthermore, they intend to study the genetic diversity of the southern white rhino, the northern white rhino's closest relative, to pinpoint the hallmarks of a resilient population.

    Ben Lamm, CEO of Colossal, expressed enthusiasm about the collaboration, emphasizing their shared dedication to preserving biodiversity for future generations. As the rapid rate of species loss continues to outpace traditional conservation methods, such novel approaches become essential. By 2050, if current trends persist, we might witness the disappearance of up to 50% of all biodiversity. While many conservation initiatives target landscape preservation and anti-poaching measures, the situation of the northern white rhino accentuates the urgency for advanced technological interventions.

    Colossal and BioRescue hope that their partnership will serve as a template for future global conservation efforts. Jan Stejskal, from Dvůr Králové, highlighted the international nature of this collaboration, involving top-tier scientists, conservationists, and zoo experts from across the globe. Their combined approach hopes to set a new standard in conservation, potentially shaping the direction of future international endeavors to protect endangered species.
    ​

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