The New York Times has a good article on the current technology in use at Pacific Biosciences in Menlo Park.
S.M.R.T. sequencing (Single Molecule Real Time) Sounds like 454 on steroids. Instead of a "picotiter plate" and pyrophosphate detection, these guys are using a "zero mode waveguide" and phospho-linked fluors.
All I can think of is that old Simpson's episode...
S.M.R.T. sequencing (Single Molecule Real Time) Sounds like 454 on steroids. Instead of a "picotiter plate" and pyrophosphate detection, these guys are using a "zero mode waveguide" and phospho-linked fluors.
All I can think of is that old Simpson's episode...
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